New Dietary Ingredient (NDI) Notification is a process mandated by the U.S. FDA for any dietary supplement containing ingredients not marketed in the U.S. before October 15, 1994. Manufacturers or distributors must provide evidence demonstrating these new ingredients’ safety before marketing the product.

Let’s say you want to make a new kind of vitamin or supplement to help people stay healthy. Before you can sell it, you must notify the FDA about your new ingredients. The notification includes details about the ingredients, the supplement, recommended usage, and evidence of safety.

Compliance with this process is essential for ensuring consumer safety and adherence to FDA regulations.